Hemostatic paste and methods of making thereof
AssigneesGuangzhou Bioseal Biotech Co., Ltd., Johnson & Johnson China Ltd., Ethicon, Inc.
InventorsDengmin Feng, Ling Teng, Yanhui Zhang, Guojun Ni, Yufu Li, Xiang Wan
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Abstract
The present invention is directed to a flowable hemostatic paste comprising a crosslinked carboxymethyl cellulose and at least one non-toxic dispersant. More specifically the present invention relates to a hemostatic paste containing citric acid cross-linked CMC, which is suspended or dispersed as a powder in a mixture of a first non-toxic glycerol-containing hygroscopic dispersant and a second non-toxic alcohol functionalized dispersant comprising propylene glycol or 1,3-butanediol.
Claims19
A flowable hemostatic paste comprising:
- A xerogel crosslinked milled polysaccharide dispersed within a substantially anhydrous blend of
- i. A glycerol-containing dispersant and
- ii. An alcohol-functionalized dispersant selected from the group consisting of propylene glycol and 1,3-Butanediol or mixtures thereof,
- wherein the paste has a moderate viscosity at rest and room temperature and provides a substantially homogenous dispersion of the crosslinked polysaccharide, and wherein the glycerol-containing dispersant is present in said paste at 10% to 30% by weight, and the alcohol-functionalized dispersant is present in said paste at 10% to 30% by weight.
Dependencies are inferred from the claim text.