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US 10,731,137 B2Granted
Lactaldehyde reductases for the production of 1,2-propanediol
AssigneeMetabolic Explorer
InventorsGwénaëlle Corre, Pascale Aliprandi
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Abstract
The present invention relates to new lactaldehyde reductase (LAR) enzymes useful for the production of 1,2-propanediol and to microorganisms overexpressing said enzymes. The invention also relates to a method for producing 1,2-propanediol by converting lactaldehyde into 1,2-propanediol with said enzymes.
Claims5
A method for producing 1, 2-propanediol, comprising the steps of:
- a) culturing a recombinant microorganism in a culture medium comprising a carbon source, wherein said microorganism is genetically modified to comprise at least one pathway for the production of (R), (S) and/or (R,S) lactaldehyde and wherein said microorganism is genetically modified to overexpress at least one of YiaY, functional fragments, and functional mutants thereof having lactaldehyde reductase activity,
- wherein the YiaY, functional fragments, and functional mutants thereof having lactaldehyde reductase activity converts said (R), (S) and/or (R,S) lactaldehyde into 1, 2-propanediol, and
- b) recovering said 1,2-propanediol from the microorganism or cell culture medium.
Dependencies are inferred from the claim text.