Protective molecules against anthrax toxin

A method of inhibiting anthrax caused by exposure to Bacillus anthracis in a subject in need thereof, said method comprising administering an effective amount of a compound, or pharmaceutically acceptable salt thereof, to the subject, wherein the compound has the formula:

• wherein
• R1 is independently hydrogen, halogen, —CX33, —OCX33, —CN, —C(O)OH, —CONH2, —NO2, —SO2Cl, —SO2NH2, —NHNH2, —NHSO2CH3, —N3, —NR11CR12C, —OR13C, —SR14C, substituted alkyl, substituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R2 is independently hydrogen, halogen, —CX33, —OCX33, —CN, —C(O)OH, —CONH2, —NO2, —SO2Cl, —SO2NH2, —NHNH2, —NR11CR12C, —OR13C, —SR14C, substituted or unsubstituted alkyl, unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R3 is independently hydrogen, halogen, —CX33, —OCX33, —CN, —C(O)OH, —CONH2, —NO2, —SO2Cl, —SO2NH2, —NHNH2, —NHSO2CH3, —N3, —NR11CR12C, —OR13C, —SR14C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• each R4 is independently hydrogen, halogen, —CX33, —OCX33, —CN, —C(O)OH, —CONH2, —NO2, —SO2Cl, —SO2NH2, —NHNH2, —NHSO2CH3, —N3, —NR11CR12C, —OR13C, —SR14C, substituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R5 is independently hydrogen, —Cl, —Br, —I, —OCX33, —CN, —C(O)OH, —CONH2, —NO2, —SO2Cl, —SO2NH2, —NHNH2, —NHSO2CH3, —N3, —NR11CR12C, —OR13C, —SR14C, unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• wherein (i) at least one of R1, R2, R3, R4, or R5 of Formula IV is not hydrogen;
• and (ii) at least one of R2, R3, or R4 of Formula V is not hydrogen;
• R6 is hydrogen or unsubstituted alkyl;
• R7 is O, S, or NH;
• each R8 is independently halogen, —CX3, —OCX3, —CN, —C(O)OH, —CONH2, —NO2, —SO2Cl, —SO2NH2, —NHNH2, —NHSO2CH3, —N3, —NR11R12, —OR13, —SR14, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R9 is hydrogen;
• each R11, R12, R13, and R14 is independently a hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R10 is hydrogen, halogen, —C(X2)3, —OC(X2)3, —CN, —C(O)OH, —CONH2, —NO2, —SO2Cl, —SO2NH2, —NHNH2, —NHSO2CH3, —N3, —NR11BR12B, —OR13B, —SR14B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• R11A, R12A, R13A, R14A, R11B, R12B, R13B, R14B, R11C, R12C, R13C, and R14C are independently a hydrogen, substituted or unsubstituted alkyl, unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• L1 is —S—;
• each X is independently a halogen;
• X1, X2 and X3 are independently a halogen;
• and
• wherein the compound is not any of