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US 10,729,879 B2Granted
Self-clearing catheters and methods of use thereof
AssigneePurdue Research Foundation
InventorHyowon Lee
Life of this patent
Estimating the term…
Abstract
Methods and catheters suitable for removing or reducing the formation of cellular occlusion associated the catheters. The catheters include a surface coated or infused with magnetic nanoparticles. Once the catheter is implanted in a subject, the nanoparticles induce localized hyperthermia around the catheter in response to a magnetic field.
Claims8
A self-clearing cannula for placement in a patient, comprising:
- an elongated tube portion having an inner surface and an oppositely disposed outer surface, a first end fluidically connectable to a fluid source outside the patient and a second, oppositely disposed end for fluidically communicating with the patient;
- plurality of magnetic nanoparticles operationally connected to at least a portion of the cannula;
- wherein the plurality of magnetic particles are positioned 20 microns from the outer surface;
- wherein the magnetic particles are present in a concentration 200 mg/ml;
- wherein the respective magnetic nanoparticles may be energized by an applied oscillating magnetic field with a field strength of 40 kA/m and with a frequency of 2 MHz to heat the cannula;
- wherein the respective magnetic nanoparticles are superparamagnetic particles larger than 100 nm in diameter.
3 more elements
A self-cleaning cannula device comprising:
- an elongated tube portion defining an inner surface and an oppositely disposed outer surface and a first end fluidically connectable to a fluid source and a second, oppositely disposed end for fluidically communicating with a patient;
- and
- a plurality of superparamagnetic nanoparticles operationally connected to at least a portion of the cannula;
- wherein the plurality of superparamagnetic particles are positioned 20 microns from the inner surface;
- wherein each superparamagnetic particle is greater than 100 nm in diameter;
- wherein the superparamagnetic particles are present in a concentration of 200 mg/ml;
- wherein the respective superparamagnetic nanoparticles may be energized by an applied oscillating magnetic field with a frequency of about 2 MHz to heat the cannula.
4 more elements
A self-cleaning cannula apparatus comprising:
- an elongated tube portion defining an inner surface and an oppositely disposed outer surface and a first end fluidically connectable to a fluid source and a second, oppositely disposed end for fluidically communicating with a patient;
- and
- a plurality of superparamagnetic nanoparticles operationally connected to at least a portion of the cannula;
- wherein the plurality of superparamagnetic particles are positioned and 20 microns from a respective surface;
- wherein each superparamagnetic particle is greater than 100 nm in diameter;
- wherein the superparamagnetic particles are present in a concentration of 200 mg/ml;
- wherein the respective superparamagnetic nanoparticles may be energized by an applied oscillating magnetic field with a field strength of 40 kA/m.
4 more elements
Dependencies are inferred from the claim text.