Self-sealing pad for a needle-based infusion set

A needle assembly, comprising:

• a handle portion, comprising:
• a needle having a proximal end secured in the handle portion and a distal end extending from the handle portion;
• and
• an extension tube secured in the handle portion to establish fluid communication with a lumen of the needle;
• a base portion releasably coupled to the handle portion in a needle assembly use configuration, the base portion comprising:
• a bottom external surface having an opening;
• a safety assembly including a needle safety component;
• and
• a self-sealing pad covering the bottom external surface, the self-sealing pad comprising:
• an antimicrobial component;
• an upper surface designed to mate with the base portion;
• a raised portion compressively positioned in the opening of the bottom external surface;
• and
• a skin-contacting surface,
• wherein the needle assembly is configured to be placed on skin such that the needle passes through the self-sealing pad and the skin.