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US 10,725,045 B2Granted
Quantifying MGMT protein for optimal cancer therapy of glioblastoma
AssigneeNantOmics, LLC
InventorsTodd A. Hembrough, Fabiola Cecchi, Dongyao Yan
Life of this patent
Estimating the term…
Abstract
Methods are provided for treating a cancer patient suffering from a glioblastoma (GBM) by administering to the patient an effective amount of temozolomide, wherein a mass spectrometry analysis of a protein digest of a formalin-fixed tumor sample from the patient evidences an amount of a MGMT fragment peptide less than or substantially equal to 150 amol/μg.
Claims16
A method of treating a patient suffering from glioblastoma cancer comprising:
- administering to the patient an effective amount of temozolomide, wherein a mass spectrometry analysis of a protein digest of a formalin-fixed glioblastoma tumor sample from the patient evidences an amount of a MGMT fragment peptide according to SEQ ID NO:1 less than or equal to 150 amol/μg.
Dependencies are inferred from the claim text.