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US 10,718,771 B2Granted
Recombinant baculoviruses and their uses in detecting arthropod-borne virus
AssigneeChung Yuan Christian University
InventorsTzong-Yuan Wu, Szu-Cheng Kuo, Pei-Yun Shu, Chang-Chi Lin, Der-Jiang Chiao, Ying-Ju Chen, Yi-Ting Lin, Shu-Fen Chang, Chien-Ling Su
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Abstract
Disclosed herein are recombinant baculoviruses suitable for detecting the presence of arthropod-borne viruses in a biological sample of a test subject. The information derived from the detection may also be used to render a diagnosis on whether the test subject is infected with the arthropod-borne viruses or not, so that proper course of treatment may be assigned to the subject.
Claims4
A method of detecting an antibody against an arthropod-borne virus in a biological sample, comprising:
- mixing the biological sample with a recombinant baculovirus having a viral protein of the arthropod-borne virus expressed thereon, wherein the arthropod-borne virus is Chikunguny a virus (CHIKV), and the viral protein comprises E1, E2, and E3;
- and
- detecting a complex formed between the recombinant baculovirus and the antibody against the arthropod-borne virus in the biological sample, in an immunological assay.
Dependencies are inferred from the claim text.