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US 10,718,765 B2Granted
Biomarkers and methods for measuring and monitoring juvenile idiopathic arthritis activity
AssigneeCrescendo Bioscience, Inc.
InventorsScott Eastman, Eric Sasso
Life of this patent
Estimating the term…
Abstract
Biomarkers useful for assessing inflammatory disease or flare activity, in particular in juvenile idiopathic arthritis, are provided, along with kits for measuring expression of the biomarkers. The invention also provides predictive models, based on the biomarkers, as well as computer systems, and software embodiments of the models for scoring and optionally classifying samples.
Claims7
A method for treating a subject having juvenile idiopathic arthritis (JIA) the method comprising:
- providing a test sample comprising a sample of bodily fluid taken from the subject;
- determining a sample concentration for a combination of three or more biomarkers selected from the group comprising C-reactive protein (CRP);
- epidermal growth factor (EGF);
- interleukin 6 (IL-6);
- leptin (LEP);
- matrix metalloproteinase-1 (MMP1);
- matrix metalloproteinase-3 (MMP3);
- resistin (RETN);
- serum amyloid (SAA);
- tumor necrosis factor receptor, type 1 (TNF-R1);
- vascular cell adhesion molecule-1 (VCAM1);
- vascular endothelial growth factor A (VEGF-A);
- and YKL-40;
- calculating, using the sample concentrations, a JIA disease activity significantly greater than found for a combination of concentrations of corresponding control biomarkers that are indicative of JIA;
- and
- administering a JIA therapeutic regimen, wherein the therapeutic regimen comprises administering a therapeutic compound selected from DMARDs, biologic DMARDs, non-steroidal anti-inflammatory drugs (NSAID's), and corticosteroids, or administering physical therapy, dietary modification and/or supplementation, or administering bariatric surgical intervention.
13 more elements
Dependencies are inferred from the claim text.