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US 10,717,787 B1Granted
Antibodies to symmetrically dimethylated arginine analytes and use thereof
AssigneeARK Diagnostics, Inc.
InventorsJohnny Valdez, Byung Sook Moon, Ki Chung, Yunfei Chen
Life of this patent
Estimating the term…
Abstract
Disclosed is an antibody which binds to a symmetrically dimethylated arginine analyte that can be used to detect a symmetrically dimethylated arginine analyte in a sample, such as in a homogeneous enzyme immunoassay method.
Claims20
An antibody that specifically binds to a compound of Formula 1:
- wherein:
- R1 is —Y—Z;
- Y is a linking group;
- and
- Z is selected from the group consisting of hydrogen, OH, SH, S-acyl, O-alkyl, halogen, NH2, epoxy, maleimidyl, haloacetamide, carboxyl, activated carboxyl, an immunogenic carrier, a protein, a label, and a solid support, and wherein the antibody is selected from the group consisting of:
- an antibody comprising:
- a variable heavy chain (VH) polypeptide comprising
- a VH CDR1 comprising the amino acid sequence GFSLSSY (SEQ ID NO:2),
- a VH CDR2 comprising the amino acid sequence DIKTGDR (SEQ ID NO:3), and
- a VH CDR3 comprising the amino acid sequence ARVYVSGNDHYDL (SEQ ID NO:4);
- and
- a variable light chain (VL) polypeptide comprising
- a VL CDR1 comprising the amino acid sequence QSISNY (SEQ ID NO:6),
- a VL CDR2 comprising the amino acid sequence RAS (SEQ ID NO:7), and
- a VL CDR3 comprising the amino acid sequence QLGYTYSNVENA (SEQ ID NO:8);
- an antibody comprising:
- a variable heavy chain (VH) polypeptide comprising
- a VH CDR1 comprising the amino acid sequence GFSLSSY (SEQ ID NO:2),
- a VH CDR2 comprising the amino acid sequence DIKTGDR (SEQ ID NO:3), and
- a VH CDR3 comprising the amino acid sequence ARVYVSGNDHYDL (SEQ ID NO:4);
- and
- a variable light chain (VL) polypeptide comprising
- a VL CDR1 comprising the amino acid sequence QSISNY (SEQ ID NO:6),
- a VL CDR2 comprising the amino acid sequence RAS (SEQ ID NO:7), and
- a VL CDR3 comprising the amino acid sequence QLGYTYTNVENA (SEQ ID NO:
- 10);
- an antibody comprising:
- a variable heavy chain (VH) polypeptide comprising
- a VH CDR1 comprising the amino acid sequence GFSFSSTK (SEQ ID NO:12),
- a VH CDR2 comprising the amino acid sequence CIGTDT (SEQ ID NO:13), and
- a VH CDR3 comprising the amino acid sequence ARSSSTGYYNL (SEQ ID NO:14);
- and
- a variable light chain (VL) polypeptide comprising
- a VL CDR1 comprising the amino acid sequence QSIRSY (SEQ ID NO:16),
- a VL CDR2 comprising the amino acid sequence YAS (SEQ ID NO:17), and
- a VL CDR3 comprising the amino acid sequence HDYYTFTDND (SEQ ID NO:18);
- an antibody comprising:
- a variable heavy chain (VH) polypeptide comprising
- a VH CDR1 comprising the amino acid sequence GFSFSSTK (SEQ ID NO:12);
- a VH CDR2 comprising the amino acid sequence CIGVGSRGS (SEQ ID NO:20);
- and
- a VH CDR3 comprising the amino acid sequence ARSSTTGYYIL (SEQ ID NO:21);
- and
- a variable light chain (VL) polypeptide comprising
- a VL CDR1 comprising the amino acid sequence ESIYSY (SEQ ID NO:23);
- a VL CDR2 comprising the amino acid sequence KAS (SEQ ID NO:24);
- and
- a VL CDR3 comprising the amino acid sequence QNYYTFTEND (SEQ ID NO:25);
- and
- an antibody comprising:
- a variable heavy chain (VH) polypeptide comprising
- a VH CDR1 comprising the amino acid sequence GFSFWR (SEQ ID NO:27);
- a VH CDR2 comprising the amino acid sequence CIDGGNTNR (SEQ ID NO:28);
- and
- a VH CDR3 comprising the amino acid sequence ARVRLGNNDYIDL (SEQ ID NO:29);
- and
- a variable light chain (VL) polypeptide comprising
- a VL CDR1 comprising the amino acid sequence QSISNY (SEQ ID NO:6);
- a VL CDR2 comprising the amino acid sequence RAS (SEQ ID NO:7);
- and
- a VL CDR3 comprising the amino acid sequence QQGYNWDLDGA (SEQ ID NO:31).
58 more elements
Dependencies are inferred from the claim text.