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US 10,710,958 B2Granted
Carbamoyl phenylalaninol compounds and uses thereof
AssigneeJazz Pharmaceuticals Ireland Limited
InventorsFionn Hurley, Lawrence Patrick Carter
Life of this patent
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Abstract
The present invention relates to carbamoyl phenylalaninol compounds and methods of using the same to treat disorders.
Claims20
A method of treating excessive daytime sleepiness or fatigue, in a subject in need thereof, comprising administering to the subject a compound of Formula I:
- wherein
- R is optionally substituted lower alkyl of 1 to 8 carbon atoms, halogen, optionally substituted alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, cyano, trifluoromethyl, or optionally substituted thioalkoxy containing 1 to 3 carbon atoms;
- x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;
- R1, R2, and R3 are independently hydrogen, optionally substituted lower alkyl of 1 to 8 carbon atoms, optionally substituted aryl, optionally substituted arylalkyl, or optionally substituted cycloalkyl of 3 to 7 carbon atoms;
- or
- R2 and R3 can he joined to form a 5 to 7-membered heterocycle optionally substituted with a member selected from the group consisting of alkyl and aryl groups, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom;
- or a pharmaceuticallly acceptable salt thereof.
4 more elements
A method of treating nightmares and/or sleep-related disturbances associated with PTSD in a subject in need thereof, comprising administering to the subject a compound of Formula I:
- wherein
- R is optionally substituted lower alkyl of 1 to 8 carbon atoms, halogen, optionally substituted alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, cyano, trifluoromethyl, or optionally substituted thioaikoxy containing 1 to 3 carbon atoms;
- x is an integer of 0 to 3, with the proviso that R may be the same or different when x is 2 or 3;
- R1, R2, and R3 are independently hydrogen, optionally substituted lower alkyl of 1 to 8 carbon atoms, optionally substituted aryl, optionally substituted arylalkyl, or optionally substituted cycloalkyl of 3 to 7 carbon atoms;
- or
- R2 and R3 can he joined to form a 5 to 7-membered heterocycle. optionally substituted with a member selected from the group consisting of alkyl and aryl groups, wherein the heterocycle can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom;
- or a pharmaceutically acceptable salt thereof.
4 more elements
Dependencies are inferred from the claim text.