Pharmaceutical composition containing verbenone derivative for treating or preventing neurodegenerative disease
AssigneeShin Poong Pharmaceutical Co., Ltd.
InventorsWon Ki Kim, Yongseok Choi, Sumi Song
Life of this patent
Estimating the term…
Abstract
The present invention relates to a pharmaceutical composition or a functional health food comprising a verbenone derivative and pharmaceutically acceptable salts thereof as active ingredients for treating or preventing a neurodegenerative disease. More specifically, the verbenone derivative according to the present invention reduces neuronal cell death and oxidative stress, and is highly effective in preventing ischemic brain damage and inflammatory cell migration in rats, thereby providing the pharmaceutical composition or the functional health food which is useful in treating neurodegenerative diseases.
Claims8
A verbenone derivative represented by a following Formula 1 or a pharmaceutically acceptable salt thereof:
- wherein R1, R2, R3, R4 and R5 are each independently a hydrogen atom, a halogen atom, a hydroxyl group, a C1-C3 alkyl group, a C1-C3 alkoxy group, an amino group, a C1-C3 alkylamine group, a C1-C3 alkyldiamine group, a C5-C8 aromatic ring, a C5-C8 cyclic ring, or a C5-C8 heteroaromatic ring;
- X, Y and Z are each independently a carbon atom, N atom, O atom or S atom;
- and
- denotes a double bond or a single bond.
Dependencies are inferred from the claim text.