Gene/carrier complex for preventing or treating inflammatory diseases
AssigneesIndustry-University Cooperation Foundation Hanyang University, Industry-University Cooperation Foundation Hanyang University Erica Campus
InventorsYong-Hee Kim, Tae-Hwan Kim, Chul-Su Yang, Yoonsung Song, Jee-Young Chung, Sungsin Jo, So Mi Kim, Qurrat Ui Ain, Ye-Ram Kim
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Abstract
Disclosed is a gene/carrier complex for preventing or treating inflammatory diseases, including tumor necrosis factor-α converting enzyme (TNF-α converting enzyme, TACE) shRNA and a nonviral gene carrier, wherein the nonviral gene carrier includes an acetate of disulfide-linked poly(oligo-arginine) or a TFA salt of poly(oligo-aspartic acid)poly(oligo-arginine).
Claims14
A gene/carrier complex comprising:
- one or more shRNAs selected from the group consisting of SEQ ID NOS:
- 2 to 5, which inhibit expression of a tumor necrosis factor-alpha converting enzyme (a TNF-α converting enzyme, TACE);
- and
- a nonviral gene carrier,
- wherein the nonviral gene carrier comprises a trifluoroacetic acid (TFA) salt of poly(oligo-aspartic acid)(oligo-arginine).
A method of preparing a gene/carrier complex, the method comprising mixing and incubating one or more shRNAs selected from the group consisting of SEQ ID NOS:
- 2 to 5, which inhibit expression of a tumor necrosis factor-alpha converting enzyme (TNF-α converting enzyme, TACE), and a nonviral carrier,
- wherein the nonviral gene carrier comprises a trifluoroacetic acid (TFA) salt of poly(oligo-aspartic acid)(oligo-arginine).
Dependencies are inferred from the claim text.