Composition for preventing or treating inflammatory disease
AssigneeNational University Corporation Nagoya University
InventorsAkihito Yamamoto, Minoru Ueda, Hidemi Goto, Masatoshi Ishigami, Yoshihiro Matsushita, Yoshinori Hasegawa, Naozumi Hashimoto, Hirotaka Wakayama
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Abstract
A composition for preventing or treating inflammatory disease and that is effective for inflammatory disease such as fulminant hepatitis and interstitial pneumonia. For such an objective, the present uses a culture supernatant obtained by culturing dental pulp stem cells as the active ingredient of the composition for preventing or treating inflammatory disease.
Claims6
A method of treating an inflammatory disease comprising, administering to a subject in need thereof an effective amount of a composition comprising a culture supernatant, wherein the culture supernatant is obtained by a method comprising
- (1) selecting adherent cells from dental pulp cells, and
- (2) culturing the adherent cells to at least 70% confluence,
- (3) culturing the cells obtained in step (2) in serum-free liquid, and
- (4) obtaining the supernatant,
- wherein the composition does not contain dental pulp stem cells, and
- wherein the inflammatory disease is selected from the group consisting of fulminant hepatitis, hepatic cirrhosis, pulmonary fibrosis, multiple sclerosis, systemic lupus erythematosus and rheumatoid arthritis.
Dependencies are inferred from the claim text.