Applications of spermine and derivatives thereof
AssigneeGeneheal Biotechnology Co., Ltd.
InventorsWuguang Pan, Wei Zhu
Life of this patent
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Abstract
Provided are applications of spermine and derivatives thereof. On the basis of existing protein structure data and small molecule structure data, calculations and analysis are performed using software to screen and obtain compounds capable of effectively interfering with PAICS activity, reducing SAICAR synthesis, and ultimately reducing SAICAR accumulation, in order to achieve the goal of treating or reducing ADSL deficiency. A better effect in the treatment or improvement of ADSL deficiency is expected from the joint use of at least two of the described compounds.
Claims13
A method for treating or alleviating a disease comprising:
- administering a therapeutically effective amount of a compound or a pharmaceutically acceptable salt or C1-C6 amide thereof to a patient in need thereof,
- wherein the compound is spermine and the disease is ADSL deficiency.
Dependencies are inferred from the claim text.