Detection method for NTRK3 fusion
AssigneeJapanese Foundation for Cancer Research
InventorsKengo Takeuchi, Yuki Togashi, Seiji Sakata, Satoko Baba
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Abstract
A polynucleotide, which is a novel causative gene for cancer, is elucidated, and, based on this finding, provided are a method for detecting the polynucleotide, or a polypeptide encoded by the polynucleotide; a kit and a primer set for the detection; a method for screening an inhibitor of the polypeptide; and a pharmaceutical composition for treating a cancer containing the inhibitor. In the detection method of the present invention, an NTRK3 fusion protein, or a fusion gene encoding the fusion protein, or an ETV6 fusion protein, or a fusion gene encoding the fusion protein, in a sample derived from the digestive system obtained from a subject, is detected.
Claims3
A method for detecting an Ets Variant6 (ETV6)-Neutrophic Tyrosine Kinase, Receptor, Type3 (NTRK3) fusion gene, comprising the steps of:
- preparing a colorectal cancer tissue obtained from a subject, and
- detecting the cleavage of a gene encoding an ETV6 protein or an NTRK3 protein, or the presence of a fusion gene encoding a fusion protein constructed from the ETV6 protein and the NTRK3 protein.
Dependencies are inferred from the claim text.