Methods and kits for assessing the risk of developing or diagnosing endometrial cancer
AssigneeChang Gung Memorial Hospital, Linkou
InventorsChyong-Huey Lai, Lan-Yan Yang, Chiao-Yun Lin, Angel Chao
Life of this patent
Estimating the term…
Abstract
Methods for diagnosing or predicting the risk of developing endometrial cancer in a subject in need of such diagnosis or risk prediction are provided, comprising measuring the expression level of at least two miRNAs disclosed herein in the sample of the subject, and compared the expression level of at least two of the miRNAs in the test sample with that of the endometrial cancer-free sample. Kits for diagnosing or predicting the risk of developing endometrial cancer, containing an agent for sequencing or measuring the expression level of at least two miRNAs disclosed herein.
Claims8
A method for detecting endometrial cancer or predicting the risk of developing endometrial cancer and treating endometrial cancer in a subject, comprising
- (a) measuring the expression level of at least one miRNA selected from the group consisting of miR28-3p, miR29a, miR 451, miR30a*, miR30b, miR30e, miR3613-5p, miR4487 and miR660 in the test sample of the subject,
- wherein the higher expression level of at least one of the following miRNA, relative to the expression level of at least one corresponding miRNAs in an endometrial cancer-free sample, is indicative of the subject having endometrial cancer or has a risk of developing endometrial cancer:
- miR660, miR28-3p, miR29a, miR30a*, miR30b, miR30e, or miR451, and
- wherein in a lower expression level of at least one of the following miRNA in the test sample, relative to the expression level of at least one corresponding miRNA in an endometrial cancer-free sample, is indicative of the subject having endometrial cancer or has a risk of developing endometrial cancer:
- miR-3613-5P or miR4487;
- and
- (b) administering to the subject in need thereof a therapeutic agent that is efficacious to inhibit endometrial cancer.
Dependencies are inferred from the claim text.