US 10,704,102 B2 · Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline

Abstract

The present invention provides a method of diagnosing the existence or risk of hyperthyroidism in a feline comprising measuring the level of expression of one or more biomarkers selected from the group consisting of, e.g., IYD, TG, SLC5A5, NIS, TPO, TSHR, DUOX1, DUOX2 (ThOX), TGFB1, CSTD, DCN and SEPP1 and the expression products thereof, in a biological sample from the feline, wherein elevated expression of the one or more biomarkers in the sample relative to a control value for expression in a sample from a normal feline or feline population, or a baseline value from the feline, indicates the existence or risk of hyperthyroidism; a method of treating a feline so diagnosed; and compositions, reagents and kits for carrying out the specified methods.

Claims20

Dependent claims

A method of treating a feline suffering from hyperthyroidism, the method comprising:

measuring an increase of at least a three fold change in the level of expression of one or more biomarkers in a sample from a feline to a control value for expression in a sample from a normal feline or population of felines, and/or relative to a previous individual baseline value from the feline;
identifying the feline having an increase of at least three fold change in the level of expression as suffering from hyperthyroidism;
and
treating the feline identified as suffering from hyperthryoidism by dietary intervention,
wherein treating the feline by dietary intervention comprises feeding the feline a diet comprising iodine in an amount of less than 0.35 mg/kg, selenium in an amount of less than 0.1 mg/kg, and/or arachidonic acid in an amount of less than or equal to 0.2%, and
wherein the one or more biomarkers exhibiting the increase in the level of expression comprises TPO.

3 more elements

A method of treating a feline suffering from hyperthyroidism, the method comprising:

measuring an increase of at least a three fold change in the level of expression of one or more biomarkers in a sample from a feline to a control value for expression in a sample from a normal feline or population of felines, and/or relative to a previous individual baseline value from the feline;
and
identifying the feline having an increase of at least three fold change in the level of expression as suffering from hyperthyroidism;
and
treating the feline identified as suffering from hyperthyroidism by pharmaceutical intervention,
wherein treating the feline by pharmaceutical intervention comprises administering an effective amount of a drug which inhibits production of T-4, administering radioiodine therapy, and/or performing a surgical thyroidectomy, and
wherein the one or more biomarkers exhibiting the increase in the level of expression comprises TPO.

4 more elements

A method of treating a feline suffering from hyperthyroidism, the method comprising:

measuring an increase of at least a three fold change in the level of expression of one or more biomarkers in a sample from a feline to a control value for expression in a sample from a normal feline or population of felines, and/or relative to a previous individual baseline value from the feline;
and
identifying the feline having an increase of at least three fold change in the level of expression as suffering from hyperthyroidism;
and
treating the feline identified as suffering from hyperthyroidism by pharmaceutical intervention,
wherein treating the feline by pharmaceutical intervention comprises administering a drug selected from methimazole or carbimazole, and
wherein the one or more biomarkers exhibiting the increase in the level of expression comprises TPO.

4 more elements

Dependencies are inferred from the claim text.

Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline

Life of this patent

Compositions and methods for diagnosing and monitoring hyperthyroidism in a feline

Life of this patent

Abstract

Claims20