Method for detection of a genetic variant

A detection kit for performing a method of detecting a genetic variant associated with a disease or disorder, including incompatibility with a pharmaceutical,

• wherein the kit comprises a nano-particle coupled to at least one first morpholino nucleic acid probe comprising a target complimentary region comprising a base sequence that is a perfect match to the genetic variant sequence associated with the disease or disorder, including incompatibility with the pharmaceutical,
• wherein the genetic variant is associated with a SNP of the gene encoding dihydropyrimidine dehydrogenase (DPD), said SNP resulting in incompatibility with the pharmaceutical fluorouracil;
• or the genetic variant is associated with a SNP of the gene encoding CYP2C19 enzyme, said SNP resulting in incompatibility of the pharmaceutical clopidogrel;
• or the genetic variant is associated with the allelic variation of the gene encoding human leukocyte antigen, said allelic variant resulting in incompatibility of the pharmaceutical carbamazepine.