Diagnosis and treatment of genetic alterations associated with eosinophilic esophagitis

A method for treating eosinophilic esophagitis (EoE) in a human subject in need thereof, the method comprising:

• (a) obtaining a biological sample from the subject;
• (b) detecting in the sample the presence of at least one EoE associated single nucleotide polymorphisms (SNP) in a target nucleic acid in said sample, wherein said SNP is present in a gene sequence from ANKDR27, said SNPs being selected from a C allele at rs3815700 in ANKRD27, and a G allele at rs10410895 in ANKRD27 and;
• and
• (c) administering to the subject an agent that ameliorates EoE symptoms.