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US 10,704,063 B2Granted
Process for the biological production of methacrylic acid and derivatives thereof
AssigneeLucite International UK Limited
InventorsGraham Ronald Eastham, Gill Stephens, Andrew Yiakoumetti
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Abstract
A process of producing methacrylic acid and/or derivatives thereof including the following steps: (a) biologically converting isobutyryl-CoA into methacrylyl-CoA by the action of an oxidase; and (b) converting methacrylyl-CoA into methacrylic acid and/or derivatives thereof. The invention also extends to microorganisms adapted to conduct the steps of the process.
Claims17
A process of producing methacrylic acid and/or derivatives thereof comprising the following steps:
- (a) biologically converting isobutyryl-CoA into methacrylyl-CoA by action of an oxidase, the oxidase is an acyl-CoA oxidase that is ACX4 from Arabidopsis thaliana;
- and
- (b) converting methacrylyl-CoA into methacrylic acid and/or derivatives thereof.
A process of producing methacrylic acid comprising the following steps:
- (a) converting isobutyryl-CoA into methacrylyl-CoA by action of an oxidase, the oxidase is an acyl-CoA oxidase that is ACX4 from Arabidopsis thaliana;
- and
- (b) biologically converting methacrylyl-CoA into methacrylic acid by the action of a thioesterase, transferase, synthetase, and/or a phosphotransacylase and a short chain fatty acid kinase.
Dependencies are inferred from the claim text.