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US 10,704,049 B2Granted
Lin28/let-7 crystal structures, purification protocols, and molecular probes suitable for screening assays and therapeutics
AssigneePresident and Fellows of Harvard College
InventorsPiotr Sliz, Yunsun Nam
Life of this patent
Estimating the term…
Abstract
The invention provides compositions and methods for regulating microRNA (miRNA) biogenesis. The invention also relates to compositions and methods for treating or preventing cancer in a subject in need thereof.
Claims4
A crystalline molecule comprising Lin28a or a crystalline molecular complex comprising Lin28a and a let-7, wherein the crystalline molecule or complex forms in a space group selected from the group consisting of P43212, P41212 and C2221.
Dependencies are inferred from the claim text.