Albumin production and cell proliferation
AssigneeMina Therapeutics Limited
InventorPål Sætrom
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Abstract
The present invention provides short activating RNA molecules which up-regulate albumin production. The present invention also provides methods of up-regulating albumin production, such methods involving the use of short activating RNA molecules capable of increasing the expression of albumin. The present invention also provides the use of the short activating RNA molecules in therapy, such as treating or preventing a hyperproliferative disorder and/or a disorder characterised by hypoalbuminemia.
Claims13
A synthetic short activating RNA (saRNA) which up-regulates the expression of a target gene, wherein the target gene is HNF4a,
- wherein the saRNA comprises an antisense strand that has at least 95% sequence identity to a sequence located on the coding strand of the target gene between 500 nucleotides upstream and 500 nucleotides downstream of the transcription start site of the target gene, and
- wherein said strand has 13-30 nucleotides in length.
A synthetic short activating RNA (saRNA) which up-regulates the expression of a target gene, wherein the target gene is HNF4a, and wherein the saRNA is double stranded and comprises an anti-sense strand having a sequence selected from SEQ ID NOs:
- 26, 28, 30, 32, 34 and 36.
Dependencies are inferred from the claim text.