Nucleic acid nanostructures with core motifs

A spherical nucleic acid (SNA) comprising, a dense configuration of oligonucleotides radially positioned around a core, wherein the oligonucleotides have a length of 8-200 nucleotides and include at least one GGG, wherein the oligonucleotides are antisense oligonucleotides, wherein the oligonucleotides comprise the following structure:

• 5′ X1GGGX2 3′
• wherein X1 and X2 are, independent of one another, any nucleotide;
• wherein the core is a liposomal core that comprises a lipid bilayer,
• wherein the oligonucleotides are single-stranded,
• wherein the oligonucleotides are indirectly linked to the core through a linker,
• wherein the oligonucleotides have an mRNA target, and wherein the mRNA target is interleukin-17 receptor A1 (IL17RA).