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US 10,704,035 B2Granted
Compositions and methods for treatment of pain
AssigneesPresident and Fellows of Harvard College, Massachusetts Institute of Technology
InventorsR. John Collier, Isaac Chiu, Bradley L. Pentelute
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Abstract
Embodied herein are engineered fusion proteins that bind and target nociceptor neurons, compositions comprising these engineered fusion proteins, and methods for treatment of pain using these engineered fusion proteins or compositions containing the engineered fusion proteins. The engineered fusion proteins contain domains derived from protein toxins such as the anthrax toxin, clostridial botulinum family of toxins, disulphide-containing toxins, and AB component type toxins.
Claims15
A fusion protein comprising:
- a) a botulinum neurotoxin (BTx) moiety, wherein the BTx moiety comprises an enzymatic moiety and a translocation domain and b) a targeting moiety comprising a C-terminal receptor-binding domain of an anthrax toxin protective antigen (PA), wherein the C-terminal receptor-binding domain of PA comprises a PAd4 domain, wherein part (a) and (b) are linked or fused together.
Dependencies are inferred from the claim text.