Retrovirus packaging cell
AssigneeUCL Business PLC
InventorsMartin Pulé, Leila Mekkaoui, Gordon Weng-Kit Cheung
Life of this patent
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Abstract
The present invention relates to a retrovirus packaging cell which expresses a temperature sensitive RNA-dependent-RNA polymerase (RdRp).
Claims19
A retrovirus packaging cell which expresses a temperature sensitive RNA-dependent-RNA polymerase (RdRp), wherein the temperature sensitive RdRp comprises the sequence shown as SEQ ID NO:
- 2 or a variant thereof.
A retroviral nucleic acid transfer vector which comprises at least one RdRp promoter element which enables the retroviral nucleic acid transfer vector to be replicated by the RdRp, wherein the RdRp comprises the sequence shown as SEQ ID NO:
- 2 or a variant thereof.
A retroviral helper element nucleotide sequence comprising at least one RdRp promoter element which enables a nucleic acid sequence which encodes a retroviral protein to be replicated by the RdRp, wherein the RdRp comprises the sequence shown as SEQ ID NO:
- 2 or a variant thereof.
Dependencies are inferred from the claim text.