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US 10,703,942 B2Granted
Low cytotoxicity switchable adhesive compositions, medical dressings and skin coverings, and methods of treatment using same
AssigneeLumina Adhesives AB
InventorMats Tunius
Life of this patent
Estimating the term…
Abstract
Low cytotoxicity compositions are disclosed, most particularly for use in adhesive medical products such as wound dressings (100) and medical skin coverings including surgical incision drapes, bacterial barriers without a wound pad for covering wounds and skin closure products. Methods of treatment are also disclosed that use the adhesive medical products, for example on patients with an injury or a long-term medical condition requiring repeated application of dressings, on patients undergoing surgery, on patients after surgery and/or injury requiring a skin covering, and skin closure methods.
Claims38
A switchable adhesive composition comprising a mixture of a pressure sensitive adhesive component, curable molecules that are curable by free radical polymerization, a photoinitiator, and a stabiliser, wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is methacrylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
36 more elements
A method of making a switchable adhesive composition comprising a mixture of a pressure sensitive adhesive component, curable molecules that are curable by free radical polymerization, a photoinitiator, and a stabiliser, the method comprising:
- (i) stirring together the pressure sensitive adhesive component, the curable molecules, the photoinitiator and the stabiliser in darkness or under red light conditions;
- (ii) coating the resulting mixture onto a carrier film;
- (iii) allowing the coated mixture to dry;
- and
- (iv) applying a second carrier film to the exposed surface of the dried spread mixture;
- wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is carboxylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
42 more elements
A medical skin covering having a switchable adhesive composition comprising a mixture of a pressure sensitive adhesive component, curable molecules that are curable by free radical polymerization, a photoinitiator, and a stabiliser, wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer, C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is methacrylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
35 more elements
A method of preparing a site for surgical incision using a surgical incision drape comprising a layer of switchable adhesive composition disposed between a first carrier film and a second carrier film wherein at least one of the carrier films includes a light occlusive layer on the surface of the carrier film remote from the adhesive composition, and wherein the carrier films have a low surface energy relative to skin so that the adhesive composition adheres preferentially to skin, the method comprising:
- (i) removing the first carrier film from the surgical incision drape to expose one surface of the adhesive composition layer;
- (ii) placing the exposed surface of the adhesive composition layer on a patient's skin at the intended site for surgical incision;
- (iii) subjecting the adhesive composition layer to visible light or UV irradiation through the second carrier film to effect cure of curable molecules in the adhesive composition;
- and
- (iv) after curing of the curable molecules in the adhesive composition, removing the second carrier film to expose the other surface of the cured adhesive composition layer;
- wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is a methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is a methacrylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
42 more elements
A method of covering a wound using a bacterial barrier comprising a layer of switchable adhesive composition disposed between a first carrier film and a second carrier film wherein at least one of the carrier films includes a light occlusive layer on the surface of the carrier film remote from the adhesive composition, and wherein the carrier films have a low surface energy relative to skin so that the adhesive composition adheres preferentially to skin, the method comprising:
- (i) removing the first carrier film from the bacterial barrier to expose one surface of the adhesive composition layer;
- (ii) placing the exposed surface of the adhesive composition layer on a patient's skin over the wound;
- (iii) subjecting the adhesive composition layer to visible light or UV irradiation through the second carrier film to effect cure of curable molecules in the adhesive composition;
- and
- (iv) after curing of the curable molecules in the adhesive composition, removing the second carrier film to expose the other surface of the cured adhesive composition layer;
- wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is methacrylic acid when I is a polyepoxide or a polyol;
- and wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
42 more elements
A method of closing the edges of a wound using a skin closure device comprising a layer of switchable adhesive composition disposed between a first carrier film and a second carrier film wherein at least one of the carrier films includes a light occlusive layer on the surface of the carrier film remote from the adhesive composition, and wherein the carrier films have a low surface energy relative to skin so that the adhesive composition adheres preferentially to skin, the method comprising:
- (i) removing the first carrier film from the skin closure device to expose one surface of the adhesive composition layer;
- (ii) placing one end of the exposed surface of the adhesive composition layer on a patient's skin in the vicinity of one end of the wound;
- (iii) bringing the edges of the wound together and progressively applying the adhesive composition layer along said wound from said one end to the other end of the wound;
- (iv) subjecting the adhesive composition layer to visible light or UV irradiation through the second carrier film to effect cure of curable molecules in the adhesive composition;
- and
- (iv) after curing of the curable molecules in the adhesive composition, removing the second carrier film to expose the other surface of the cured adhesive composition layer;
- wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is methacrylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
43 more elements
A medical skin covering composition comprising a mixture comprising curable molecules that are curable by free radical polymerization, a photoinitiator, and a stabiliser, wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is methacrylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton and wherein the composition is transformable from a viscoelastic state to an elastic state upon exposure to UV light or visible light.
36 more elements
A method of applying a surgical incision drape to an intended incision site on a patient's skin using a medical skin covering composition comprising a mixture comprising curable molecules that are curable by free radical polymerization, a photoinitiator, and a stabiliser, the method comprising:
- (i) applying the composition and spreading it over the intended site of the incision;
- and
- (ii) subjecting the composition spread over the intended site of the incision to visible light or UV irradiation to effect cure of the curable molecules in the composition;
- wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is methacrylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
40 more elements
A method of applying a bacterial barrier to a wound on a patient's skin using a medical skin covering composition comprising a mixture comprising curable molecules that are curable by free radical polymerization, a photoinitiator, and a stabiliser, the method comprising:
- (i) applying the composition and spreading it over the site of the wound;
- and
- (ii) subjecting the composition spread over the site of the wound to visible light or UV irradiation to effect cure of the curable molecules in the composition;
- wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is methacrylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
40 more elements
A method of closing the edges of a wound using a medical skin covering composition comprising a mixture comprising curable molecules that are curable by free radical polymerization, a photoinitiator, and a stabiliser, the method comprising:
- (i) bringing the edges of the wound together and applying the composition and spreading it over the site of the wound;
- and
- (ii) subjecting the composition spread over the wound to visible light or UV irradiation to effect cure of the curable molecules in the composition;
- wherein the curable molecules are oligomers of at least one of the following formulae (I) to (VII):
- CA(BA)nC (I)
- where n is 0 or an integer from 1 to 100,
- A is a diisocyanate, a diepoxide, a diol or a dicarboxylic acid;
- B is a diol when A is a diisocyanate or a dicarboxylic acid;
- B is a dicarboxylic acid when A is a diepoxide or a diol;
- C is a hydroxyl containing methacrylate ester when A is a diisocyanate or a dicarboxylic acid;
- C is methacrylic acid when A is a diepoxide or a diol;
- C2E(BCE)nC (II)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- B is a diol when E is a tri-isocyanate or a tricarboxylic acid;
- B is a dicarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- E(2n+1)FnC(3n+3) (III)
- where n is 0 or an integer from 1 to 100,
- E is a tri-isocyanate, a triepoxide, a triol or a tricarboxylic acid;
- F is a triol when E is a tri-isocyanate or a tricarboxylic acid;
- F is a tricarboxylic acid when E is a triepoxide or a triol;
- C is a hydroxyl containing methacrylate ester when E is a triisocyanate or a tricarboxylic acid;
- C is methacrylic acid when E is a triepoxide or a triol;
- G(n+1)BnC(2n+4) (IV)
- where n is 0 or an integer from 1 to 100,
- G is a tetra-isocyanate or a tetra-carboxylic acid;
- B is a diol;
- C is a hydroxyl containing methacrylate ester;
- DC3 (V)
- where D is a symmetrical isocyanurate trimeric ring structure or an asymmetric trimeric iminooxadiazinedione ring structure consisting of three diisocyanate molecules, or a linear trimeric biuret or allophanate structure,
- C is a hydroxyl containing methacrylate ester;
- HxC(x+2) (VI)
- where x is 1, 2, 3, 4, 5 or 6,
- Hx is x symmetrical isocyanurate trimeric ring structures or x asymmetric trimeric iminooxadiazinedione ring structures consisting of three diisocyanate molecules, or x linear trimeric biuret or allophanate structures linked together in a homopolymer,
- C is a hydroxyl containing methacrylate ester;
- IyCy (VII)
- where y is 2, 3, 4, 5, 6, 7, 8, or 9,
- Iy is polyisocyanate, a polyepoxide, a polyol or a polycarboxylic acid with y numbers of functionalities;
- C is a hydroxyl containing methacrylate ester when I is a polyisocyanate or a polycarboxylic acid;
- C is methacrylic acid when I is a polyepoxide or a polyol;
- wherein the oligomers have a weight average molecular weight in the range from 1,500 to 10,000 dalton.
40 more elements
Dependencies are inferred from the claim text.