Sulfoalkyl ether cyclodextrin compositions and methods of preparation thereof

A pharmaceutical composition comprising a sulfoalkyl ether cyclodextrin composition and an active agent, wherein the sulfoalkyl ether cyclodextrin composition comprises:

• (a) sulfoalkyl ether cyclodextrin;
• and
• (b) no more than about 20% by weight moisture;
• and wherein the sulfoalkyl ether cyclodextrin composition has a bulk density of about 0.38 g/cm3 to about 0.66 g/cm3 and
• a tapped density of about 0.49 g/cm3 to about 0.75 g/cm3, wherein the tapped density of the sulfoalkyl ether cyclodextrin composition is higher than the bulk density;
• and
• a gravitational-flow minimum orifice diameter of about 3 mm to about 12 mm;
• and wherein the sulfoalkyl ether cyclodextrin composition comprises agglomerated particles;
• and
• wherein the active agent is an antibiotic agent, an antihistamine agent, a decongestant, an anti-inflammatory agent, an antiparasitic agent, an antiviral agent, a local anesthetic, an antifungal agent, an antibacterial agent, an amoebicidal agent, a trichomonocidal agent, an analgesic agent, an anti-arthritic agent, an anti-asthmatic agent, an anticoagulant agent, an anticonvulsant agent, an antidepressant agent, an antidiabetic agent, an antineoplastic agent, an anti-psychotic agent, a neuroleptic agent, an antihypertensive agent, a hypnotic agent, a sedative agent, an anxiolytic energizer agent, an anti-Parkinson's disease agent, an anti-Alzheimer's disease agent, a muscle relaxant agent, an antimalarial agent, a hormonal agent, a contraceptive agent, a sympathomimetic agent, a hypoglycemic agent, an anti-hyperglyceridemia agent, an anti-dyslipidemia agent, a cholesterol reducing agent, a bile acid absorption inhibitor, an antilipemic agent, an ophthalmic agent, an electrolytic agent, a diagnostic agent, a prokinetic agent, a gastric acid secretion inhibitor agent, an anti-ulcerant agent, an anti-flatulent agent, an anti-incontinence agent, a cardiovascular agent, a corticosteroid, a B2 adrenoreceptor agonist, a dopamine D2 receptor agonist, an anticholinergic agent, an IL-5 inhibitor, an antisense modulators of IL-5, milrinone lactate, tryptase inhibitor, tachykinin receptor antagonist, leukotriene receptor antagonist, 5-lypoxygenase inhibitor, anti-IgE antibody, protease inhibitor or any combinations thereof.