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US 10,703,820 B2Granted
Methods and compositions for reducing cardiac damage and other conditions
AssigneeTufts Medical Center, Inc.
InventorsNavin K. Kapur, Richard H. Karas
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AssigneeTufts Medical Center, Inc.
InventorsNavin K. Kapur, Richard H. Karas
Estimating the term…
Endoglin has been identified to play a functional role as a regulator of TGFβ1 signaling, particular in TGFβ1-mediated calcineurin expression. The present invention features methods of reducing cardiac damage, particularly in a subject undergoing chemotherapy or radiation therapy by administering a composition that inhibits endoglin activity. The present invention also features methods of treating autoimmune diseases, inflammatory diseases, organ transplantation, and conditions association with oxidative stress related to TGFβ1-mediated calcineurin expression and reactive oxygen species (ROS) production by administering a composition that inhibits endoglin activity. The present invention also features methods of treating fibrotic diseases by administering a composition that inhibits endoglin activity.
A method of treating a fibrotic disease in a human subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an interfering ribonucleic acid (RNA) that is specific for Endoglin mRNA and that reduces Endoglin expression, wherein the fibrotic disease is selected from the group consisting of lung fibrosis, kidney fibrosis, and liver fibrosis.
Dependencies are inferred from the claim text.