System for delivery into XCR1 positive cell and uses thereof
AssigneeBundesrepublik Deutschland Letzvertreten Durch Das Robert Koch-Institut Vertreten Durch Seinen Praesidenten
InventorRichard Kroczek
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Abstract
The present invention relates to a delivery system suitable for delivering a substance into a XCR1 positive professional antigen-presenting cell, one or more nucleic acids coding for the same, a vector comprising the nucleic acid(s), a medicament comprising the delivery system or the one or more nucleic acid(s) and an adjuvant comprising XCL1 or a functionally active fragment thereof.
Claims6
A method for inducing, in a subject, a memory immune response against a substance, comprising administering to the subject a delivery system, or nucleic acids encoding said delivery system, suitable for delivering the substance into a chemokine (C motif) receptor 1 (XCR1) positive professional antigen-presenting cell, the delivery system comprising
- i) a chemokine (C motif) ligand 1 (XCL1);
- ii) the substance to be delivered, wherein the substance is a peptide of a viral, bacterial, or fungal pathogenic protein or a tumor antigen, the substance being bound to the XCL1;
- and
- iii) a danger signal adjuvant,
- wherein said administering of the delivery system to the subject induces a memory immune response to the substance in the subject.
Dependencies are inferred from the claim text.