M971 chimeric antigen receptors
AssigneeThe United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsRimas J. Orentas, Ira H. Pastan, Dimiter S. Dimitrov, Crystal L. Mackall
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Abstract
The invention provides a chimeric antigen receptor (CAR) comprising an antigen binding domain comprising SEQ ID NOs: 1-6, a transmembrane domain, and an intracellular T cell signaling domain. Nucleic acids, recombinant expression vectors, host cells, populations of cells, antibodies, or antigen binding portions thereof, and pharmaceutical compositions relating to the CARs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed.
Claims18
A nucleic acid comprising a nucleotide sequence encoding a chimeric antigen receptor (CAR) comprising (a) an antigen binding domain which binds to CD22 and comprises an amino acid sequence comprising a heavy chain CDR1 comprising SEQ ID NO:
- 1, a heavy chain CDR2 comprising SEQ ID NO:
- 2, a heavy chain CDR3 comprising SEQ ID NO:
- 3, light chain CDR1 comprising SEQ ID NO:
- 4, a light chain CDR2 comprising SEQ ID NO:
- 5, and a light chain CDR3 comprising SEQ ID NO:
- 6, (b) a transmembrane domain, and (c) an intracellular T cell signaling domain.
Dependencies are inferred from the claim text.