Ligands that potentiate the bioactivity of gonadotropins
AssigneeIgyxos
InventorsElodie Kara, Jeremye Decourtye, Sophie Casteret, Marie-Christine Maurel
Life of this patent
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Abstract
The invention relates to antibodies directed against follicle-stimulating hormone (FSH) and capable of potentiating the bioactivity of gonadotropins.
Claims49
A follicle-stimulating hormone (FSH) ligand which potentiates the bioactivity of FSH, of luteinizing hormone (LH), and of chorionic gonadotropin (CG),
- wherein said ligand is an antibody or a fragment thereof, and
- the heavy chain variable domain of the antibody or the fragment contains the following CDRs:
- VH-CDR1, defined by the sequence
- (SEQ ID NO:
- 5)
- GFTFSSSY;
- VH-CDR2, defined by the sequence
- (SEQ ID NO:
- 6)
- IYAGTGGT;
- VH-CDR3, defined by the sequence
- (SEQ ID NO:
- 7)
- ARHGSYFDY;
- and
- the light chain variable domain of the antibody or the fragment contains the following CDRs:
- VL-CDR1, defined by the sequence
- (SEQ ID NO:
- 8)
- QSVDYDGDSY;
- VL-CDR2, defined by the sequence
- AAS;
- VL-CDR3, defined by the sequence
- (SEQ ID NO:
- 9)
- QQSNEDPYT.
A follicle-stimulating hormone (FSH) ligand which potentiates the bioactivity of FSH, of luteinizing hormone (LH), and of chorionic gonadotropin (CG),
- wherein said ligand is an antibody or a fragment thereof, and
- the heavy chain variable domain of the antibody or the fragment contains the sequence of SEQ ID NO:
- 2 or 30;
- and
- the light chain variable domain of the antibody or the fragment contains the sequence SEQ ID NO:4 or 28.
A follicle-stimulating hormone (FSH) ligand which potentiates the bioactivity of FSH, of luteinizing hormone (LH), and of chorionic gonadotropin (CG),
- wherein said ligand is an antibody fragment, and
- wherein the antibody fragment contains the following CDRs:
- VH-CDR1, defined by the sequence
- (SEQ ID NO:
- 5)
- GFTFSSSY;
- VH-CDR2, defined by the sequence
- (SEQ ID NO:
- 6)
- IYAGTGGT;
- and
- VH-CDR3, defined by the sequence
- (SEQ ID NO:
- 7)
- ARHGSYFDY.
A follicle-stimulating hormone (FSH) ligand which potentiates the bioactivity of FSH, of luteinizing hormone (LH), and of chorionic gonadotropin (CG),
- wherein said ligand is an antibody fragment, and
- the heavy chain variable domain of the antibody fragment contains the sequence of SEQ ID NO:
- 2 or 30;
- or
- the light chain variable domain of the antibody fragment contains the sequence SEQ ID NO:
- 28.
Dependencies are inferred from the claim text.