Method of treatment with humanized anti-IL-18 antibodies

A method of neutralizing IL-18 in an IL-18 mediated disease or disorder in a human in need thereof, said method comprising administering to the human a therapeutically effective amount of an anti-IL1,8 antibody or antigen binding fragment thereof, wherein the anti-IL18 antibody comprises complementarity determining regions (CDRs) selected from the group consisting of:

• CDRH1 as set forth in SEQ ID NO:
• 1;
• CDRH2 as set forth in SEQ ID NO:
• 2;
• CDRH3 as set forth in SEQ ID NO:
• 3;
• CDRL1 as set forth in SEQ ID NO:
• 4;
• CDRL2 as set forth in SEQ ID NO:
• 5;
• and
• CDRL3 as set forth in SEQ ID NO:
• 6.