Methods and compositions for treating multiple sclerosis
AssigneeUniversity of Miami
InventorsRobert W. Keane, W. Dalton Dietrich, Juan Pablo De Rivero Vaccari, Helen M. Bramlett, Roberta Brambilla
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Abstract
The compositions and methods described herein include agents that inhibit inflammasome signaling in the mammal such as antibodies directed against inflammasome components used alone or in combination with extracellular vesicle uptake inhibitor(s). Also described herein are compositions and methods of use thereof for treating multiple sclerosis.
Claims6
A monoclonal antibody or an antibody fragment thereof that binds specifically to Apoptosis-associated Spec-like protein containing a Caspase Activating Recruitment Domain (ASC), wherein the antibody or the antibody fragment comprises a heavy chain variable (VH) region and a light chain variable (VL) region,
- wherein the VH region amino acid sequence comprises HCDR1 of SEQ ID NO:
- 6, HCDR2 of SEQ ID NO:
- 7 and HCDR3 of SEQ ID NO:
- 8;
- and
- wherein the VL region amino acid sequence comprises LCDR1 of SEQ ID NO:
- 12, LCDR2 of SEQ ID NO:
- 13 and LCDR3 of SEQ ID NO:
- 14.
Dependencies are inferred from the claim text.