Human anti-alpha-synuclein antibodies
AssigneesBiogen International Neuroscience GmbH, University of Zurich
InventorsAndreas Weihofen, Jan Grimm, Roger Nitsch, Christoph Hock
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Abstract
Provided are novel human α-synuclein-specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for α-synuclein are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for α-synuclein targeted immunotherapy and diagnosis, respectively.
Claims19
A method of treating a synucleinopathic disease in a human subject in need thereof, the method comprising administering to the human subject a therapeutically effective amount of an antibody that binds to human alpha-synuclein and comprises:
- (i) an immunoglobulin heavy chain comprising a heavy chain variable region (VH) comprising VH complementarity determining regions (CDRs) 1, 2, and 3 with the amino acid sequences set forth in residues 31-35 of SEQ ID NO:9, residues 50-68 of SEQ ID NO:9, and residues 101-102 of SEQ ID NO:9, respectively;
- and
- (ii) an immunoglobulin light chain comprising a light chain variable region (VL) comprising VL CDRs 1, 2, and 3 with the amino acid sequences set forth in residues 23-33 of SEQ ID NO:12, residues 49-55 of SEQ ID NO:12, and residues 88-98 of SEQ ID NO:12, respectively.
Dependencies are inferred from the claim text.