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AssigneeJanssen Vaccines & Prevention B.V.
InventorsBoerries Brandenburg, Ronald Vogels, Joost A. Kolkman, Robert Heinz Edward Friesen
Estimating the term…
Multimeric binding molecules that are capable of specifically binding to hemagglutinin (HA) of at least two influenza A virus strains, said strains comprising HA of two different HA subtypes from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically binding to hemagglutinin (HA) of at least one influenza B virus strain are provided. The binding molecules preferably are also capable of neutralizing at least two influenza A virus strains from phylogenetic group 2; or capable of neutralizing at least one influenza A virus strain from phylogenetic group 1 and at least one influenza A virus strain from phylogenetic group 2; or capable of specifically neutralizing at least one influenza B virus strain.
A single domain antibody (sdAb) comprising one of the amino acid sequences selected from the group consisting of SEQ ID NO:
A multi-domain antibody comprising a first polypeptide comprising a first single domain antibody (sdAb) comprising the amino acid sequence of SEQ ID NO:
A multi-domain antibody comprising a first polypeptide chain comprising, from N-terminus to C-terminus, a first single domain antibody (sdAb) comprising the amino acid sequence of SEQ ID NO:
A multi-domain antibody comprising a first polypeptide chain having the amino acid sequence of SEQ ID NO:
Dependencies are inferred from the claim text.