Human neutralizing antibodies binding to influenza B neuraminidase
AssigneeJanssen Vaccines & Prevention B.V.
InventorsMiriam Verena Bujny, Remko Van Der Vlugt, Donata De Marco
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Abstract
The present invention provides influenza neuraminidase (NA)-binding human antibodies, which are capable of specifically binding to and neutralizing at least one influenza B virus strain from the B/Victoria lineage and/or at least one influenza B virus strain from the B/Yamagata lineage, as well as antigen-binding fragment thereof. The invention furthermore relates to the use of said antibodies or antigen-binding fragments in the diagnosis, prophylaxis and/or treatment of influenza infection.
Claims26
A neuraminidase (NA)-binding human antibody or antigen-binding fragment thereof, wherein the antibody or antigen-binding fragment thereof is capable of specifically binding to and neutralizing at least one influenza B virus strain from the B/Victoria lineage and/or at least one influenza B virus strain from the B/Yamagata lineage, and wherein the antibody or antigen-binding fragment thereof is selected from the group consisting of:
- a) an antibody or antigen-binding fragment thereof comprising a heavy chain CDR1 sequence of SEQ ID NO:1, a heavy chain CDR2 sequence of SEQ ID NO:2, and a heavy chain CDR3 sequence of SEQ ID NO:3, and a light chain CDR1 sequence of SEQ ID NO:10, a light chain CDR2 sequence of SEQ ID NO:11, and a light chain CDR3 sequence of SEQ ID NO:12;
- b) an antibody or antigen-binding fragment thereof comprising a heavy chain CDR1 sequence of SEQ ID NO:4, a heavy chain CDR2 sequence of SEQ ID NO:5, and a heavy chain CDR3 sequence of SEQ ID NO:6, and a light chain CDR1 sequence of SEQ ID NO:13, a light chain CDR2 sequence of SEQ ID NO:14, and a light chain CDR3 sequence of SEQ ID NO:15;
- and
- c) an antibody or antigen-binding fragment thereof comprising a heavy chain CDR1 sequence of SEQ ID NO:7, a heavy chain CDR2 sequence of SEQ ID NO:8, and a heavy chain CDR3 sequence of SEQ ID NO:9, and a light chain CDR1 sequence of SEQ ID NO:16, a light chain CDR2 sequence of SEQ ID NO:17, and a light chain CDR3 sequence of SEQ ID NO:18.
A neuraminidase (NA)-binding antibody or antigen-binding fragment thereof, comprising:
- a) a heavy chain CDR1 sequence of SEQ ID NO:1, a heavy chain CDR2 sequence of SEQ ID NO:2, and a heavy chain CDR3 sequence of SEQ ID NO:3, and a light chain CDR1 sequence of SEQ ID NO:10, a light chain CDR2 sequence of SEQ ID NO:11, and a light chain CDR3 sequence of SEQ ID NO:12;
- b) a heavy chain CDR1 sequence of SEQ ID NO:4, a heavy chain CDR2 sequence of SEQ ID NO:5, and a heavy chain CDR3 sequence of SEQ ID NO:6, and a light chain CDR1 sequence of SEQ ID NO:13, a light chain CDR2 sequence of SEQ ID NO:14, and a light chain CDR3 sequence of SEQ ID NO:15;
- or
- c) a heavy chain CDR1 sequence of SEQ ID NO:7, a heavy chain CDR2 sequence of SEQ ID NO:8, and a heavy chain CDR3 sequence of SEQ ID NO:9, and a light chain CDR1 sequence of SEQ ID NO:16, a light chain CDR2 sequence of SEQ ID NO:17, and a light chain CDR3 sequence of SEQ ID NO:18.
Dependencies are inferred from the claim text.