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US 10,703,789 B2Granted
Modified polynucleotides for the production of secreted proteins
AssigneeModernaTX, Inc.
InventorsAntonin De Fougerolles, Justin Guild
Life of this patent
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Abstract
A pharmaceutical composition which has a plurality of lipid nanoparticles that has a mean particle size of between 80 nm and 160 nm and contains a modified mRNA encoding a polypeptide. The lipid nanoparticles include a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid. The mRNA contains a 5′-cap, 5′-UTR, N1-methyl-pseudouridine, a 3′-UTR, and a poly-A region with at least 100 nucleotides.
Claims14
A pharmaceutical composition comprising:
- a plurality of lipid nanoparticles comprising a cationic lipid, a neutral lipid, a cholesterol, and a PEG lipid,
- wherein the plurality of lipid nanoparticles has a mean particle size of between 80 nm and 160 nm;
- and
- wherein the lipid nanoparticles comprise an mRNA encoding a polypeptide, wherein the mRNA comprises:
- (i) at least one 5′-cap structure;
- (ii) a 5′-UTR;
- (iii) an open reading frame encoding the polypeptide and consisting of nucleotides including N1-methyl-pseudouridine, cytosine, adenine, and guanine;
- (iv) a 3′-UTR;
- and
- (v) a poly-A region of least 100 nucleotides in length.
7 more elements
Dependencies are inferred from the claim text.