Methods and compositions for improving glucose metabolism
AssigneeThe University of Melbourne
InventorsMatthew Watt, Ruth Meex
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Abstract
The present invention relates to compositions, methods and kits for promoting glucose clearance in an individual. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment of insulin resistance or type 2 diabetes. The invention provides a method of promoting blood glucose clearance in an individual, the method comprising administering SMOC1 to the individual. Preferably, the individual has an impaired ability to clear glucose from the blood. Typically, the individual displays a level of insulin resistance.
Claims23
A method of increasing glycemic control in an individual, the method comprising administering SMOC1 or a fusion protein comprising SMOC1, to the individual prior to, or after an event that raises the blood glucose level in the individual, thereby increasing glycemic control in the individual.
A method of increasing glycemic control in an individual, the method comprising administering a fusion protein comprising SMOC1 to the individual, wherein the fusion protein comprising SMOC1 comprises an Fc portion of an antibody and a SMOC1 protein, thereby increasing glycemic control in the individual.
A fusion protein comprising an amino acid sequence of SMOC1, wherein the fusion protein comprises the amino acid sequence shown in SEQ ID NO:
- 3.
A pharmaceutical composition for increasing glycemic control in an individual, the composition comprising a fusion protein comprising SMOC1 and a pharmaceutically acceptable diluent, excipient or carrier, wherein the fusion protein comprises the amino acid sequence shown in SEQ ID NO:
- 3.
Dependencies are inferred from the claim text.