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US 10,703,779 B2Granted
Oxadiazole cyclic peptides
AssigneeThe Governing Council of the University of Toronto
InventorsAndrei Yudin, John R. Frost
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Abstract
The present invention relates to cyclic amino acid molecules, in particular 1,3,4-oxadiazole containing macrocyclic peptides, and a process to produce the same. The process involves the macrocyclization of amino acids or linear peptides. Specifically, the process comprises reacting an amino acid molecule with an isocyano-iminophosphorane and an aldehyde or a ketone.
Claims27
A cyclic amino acid molecule of formula [(I)] or a salt of the foregoing:
- wherein,
- Z is an amino terminus of an amino acid;
- —C═O— is a carboxy terminus of an amino acid;
- L, along with Z and —C═O— is a linear peptide;
- R1 and R2 are each independently hydrogen or an organic group, and are optionally covalently linked to each other;
- and
- R3 is an amino acid side-chain.
4 more elements
Dependencies are inferred from the claim text.