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US 10,703,777 B2Granted
Miniature protein scaffolds and methods for use thereof
AssigneeNew York University
InventorsKent Kirshenbaum, Timothy W. Craven, Richard Bonneau
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Abstract
Miniature protein scaffolds and compositions thereof (e.g., vaccine formulations) and methods of using same are described herein. In a particular embodiment, the miniature protein scaffold comprises an isolated β-strand connected via a loop to a left-handed poly proline type-II (PPII) helix formed in the absence of proline residues.
Claims15
A miniature protein scaffold comprising:
- (a) Arg Val Arg Val Arg Thr Ser Arg Xaa Gly Tyr Asn Gly Thr Trp Ser Glu Trp Ser, wherein Xaa at position 9 is D-proline (D-Pro) and at least one of
- the arginine (Arg) at position 1, 5, or 8;
- the valine (Val) at position 2 or 4;
- the threonine (Thr) at position 6 or 14;
- the serine (Ser) at position 7, 16, or 19;
- the tyrosine (Tyr) at position 11;
- the asparagine (Asn) at position 12;
- the glycine (Gly) at position 13;
- and
- the glutamic acid (Glu) at position 17;
- is replaced by a different alpha amino acid;
- or
- (b) Arg Cys Arg Val Arg Thr Ser Arg D-Pro Gly Tyr Asn Gly Thr Trp Ser Glu Trp Cys, wherein at least one of
- the arginine (Arg) at position 1, 5, or 8;
- the valine (Val) at position 4;
- the threonine (Thr) at position 6 or 14;
- the serine (Ser) at position 7 or 16;
- the tyrosine (Tyr) at position 11;
- the asparagine (Asn) at position 12;
- the glycine (Gly) at position 13;
- and
- the glutamic acid (Glu) at position 17;
- is replaced by a different alpha amino acid.
20 more elements
Dependencies are inferred from the claim text.