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US 10,703,776 B2Granted
IL-2RBeta binding compounds
AssigneeMedikine, Inc.
InventorsWilliam J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
Life of this patent
Estimating the term…
Abstract
IL-2Rβ ligands and IL-2Rγc ligands and compounds comprising the ligands are disclosed. The ligands and compounds such as heterodimers and fusion proteins comprising the IL-2Rβ ligands and/or the IL-2Rγc ligands can be IL-2 receptor agonists.
Claims27
An IL-2Rβ ligand, wherein,
- the IL-2Rβ ligand exhibits a binding affinity (IC50) to the human IL-2Rβ subunit of less than 100 μM;
- and
- the IL-2Rβ ligand comprises an amino acid sequence selected from any one of SEQ ID NOS:
- 8, 16, 33, 59, 67, 169, 170, 171, 181, 182, 189-193, 1033-1037, 589, 621, 693, 781, 808, 814, 844, 894, 897, and 902:
- SEQ ID NO:
- 8
- D T C A I A Q L Y D L C D L
- SEQ ID NO:
- 16
- G D C Y F S Q I G E L C M L
- SEQ ID NO:
- 33
- L P C D M A D L F T L C D Y
- SEQ ID NO:
- 59
- Y E C F Q A Q V G Q L C D V
- SEQ ID NO:
- 67
- L E C W Q A Q K G D L C D L
- SEQ ID NO:
- 169
- N M C L V G D Y W P S C Q I
- SEQ ID NO:
- 170
- Q I C D V G Q W W P D C Q V
- SEQ ID NO:
- 171
- V L C D Y M N S D Y Q C I T
- SEQ ID NO:
- 181
- D L F A I W P D
- SEQ ID NO:
- 182
- L V G D L W P S
- SEQ ID NO:
- 189
- L C H V G D Y I Q D G I C M
- SEQ ID NO:
- 190
- S C Q I G E L V D L T D C A
- SEQ ID NO:
- 191
- T C Q V G D F F D W L S C A
- SEQ ID NO:
- 192
- Y A C A E N V I D W L C T
- SEQ ID NO:
- 193
- C V L L E H S S V G D I I C
- SEQ ID NO:
- 1033
- C Y E V G D Y C Q S
- SEQ ID NO:
- 1034
- C G M A I G D L C M
- SEQ ID NO:
- 1035
- C L E V G C I W D M F V
- SEQ ID NO:
- 1036
- F C D M G T V W P D L S
- SEQ ID NO:
- 1037
- D C M L Y E L C D I D V L
- SEQ ID NO:
- 589
- L V G W N H Y D C S V A R V G E L C D L
- SEQ ID NO:
- 621
- E S M G L G Y P C W R A Q L G E L C D L
- SEQ ID NO:
- 693
- Y A C W L A K V G E L C D M D E D F T I
- SEQ ID NO:
- 781
- W A F Y D C F T A Q V G E L C D L S I G
- SEQ ID NO:
- 808
- W Y P C W M A Q L G E L C D L D
- SEQ ID NO:
- 814
- W Q R E W R W F P C W M A K L G D M C D L D
- SEQ ID NO:
- 844
- W G R N R S W Y P C W M A Q L G E L C D L E
- SEQ ID NO:
- 894
- R V T W Y P C W M A Q L G E L C D L E E S V
- SEQ ID NO:
- 897
- W Y P C W M A Q L G E L C D L D D H W P A M
- SEQ ID NO:
- 902
- W Y P C W I A R L G E L C D L E T S G G F P
91 more elements
Dependencies are inferred from the claim text.