Fluoride trapping arrangement
AssigneeGe Healthcare Limited
InventorsXavier Franci, Steve Lignon, Audrey Marie Lange, Nicolas Verbrugge
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Abstract
The present invention provides a new chemical process, a new cassette configuration, and new software for the automated production of multiple batches of an [18F]labelled compound on a single cassette. The invention allows one synthesizer in one hot cell to produce sequentially a plurality of batches of [18F]-labelled PET tracer in the same day. In particular, the present invention provides a novel arrangement useful for the trapping of [18F]fluoride and recovery of [18O]water.
Claims20
A cassette system for trapping [18F]fluoride and recovering [18O]water, the cassette system comprising:
- (i) a first anion exchange column, the first anion exchange column having a first end and a second end;
- (ii) a first length of tubing fluidly connected at its second end to the second end of said first anion exchange column;
- (iii) a second anion exchange column, the second anion exchange column having a first end and a second end;
- (iv) a second length of tubing fluidly connected at its second end to the second end of said second anion exchange column;
- (v) a [18F]fluoride inlet;
- and,
- (vi) a [18O]water recovery vial;
- wherein the first end of the first anion exchange column and the first end of the second anion exchange column are fluidly connected to a common pathway within the cassette via a valve having three ports and means to put any two of the three associated ports in fluid communication with each other while fluidly isolating the third port
- wherein said first end of said first length of tubing is fluidly connected to said common pathway within the cassette at a point in between said second anion exchange column and said [18F]fluoride inlet;
- and
- said first end of said second length of tubing is fluidly connected to said common pathway within the cassette at a point in between said first anion exchange column and said [18F]fluoride inlet.
Dependencies are inferred from the claim text.