Polymorphous forms of rifaximin, processes for their production and use thereof in the medicinal preparations

A method of treating bacterial activity in the gastrointestinal tract of a subject, the method comprising:

• topically administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of rifaximin δ,
• wherein rifaximin δ has a powder X-ray diffractogram showing peaks at values of the diffraction angles 2θ of about 5.7°±0.2, 6.7°±0.2, 7.1°±0.2, 8.0°±0.2, 8.7°±0.2, 10.4°±0.2, 10.8°±0.2, 11.3°±0.2, 12.1°±0.2, 17.0°±0.2, 17.3°±0.2, 17.5°±0.2, 18.5°±0.2, 18.8°±0.2, 19.1°±0.2, 21.0°±0.2, 21.5°±0.2.

A method of treating bacterial activity in the gastrointestinal tract of a subject, the method comprising:

• orally administering to the subject by oral route a pharmaceutical composition comprising a therapeutically effective amount of rifaximin ε together with a pharmaceutically acceptable excipient selected from the group consisting of diluting, binding, lubricating, disintegrating, colouring, flavouring and sweetening agents,
• wherein rifaximin ε has a powder X-ray diffractogram showing peaks at values of the diffraction angles 2θ of 7.0°±0.2, 7.3°±0.2, 8.2°±0.2, 8.7°±0.2, 10.3°±0.2, 11.1°±0.2, 11.7°±0.2, 12.4°±0.2, 14.5°±0.2, 16.3°±0.2, 17.2°±0.2, 18.0°±0.2, 19.4°±0.2.

A method of treating bacterial activity in the gastrointestinal tract of a subject, the method comprising:

• topically administering to the subject by oral route a pharmaceutical composition comprising a therapeutically effective amount of rifaximin ε,
• wherein rifaximin ε has a powder X-ray diffractogram showing peaks at values of the diffraction angles 2θ of 7.0°±0.2, 7.3°±0.2, 8.2°±0.2, 8.7°±0.2, 10.3°±0.2, 11.1°±0.2, 11.7°±0.2, 12.4°±0.2, 14.5°±0.2, 16.3°±0.2, 17.2°±0.2, 18.0°±0.2, 19.4°±0.2.