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AssigneePfizer Inc.
InventorsAtli Thorarensen, Matthew Frank Brown, Agustin Casimiro-Garcia, Ye Che, Mark Edward Flanagan, Adam Matthew Gilbert, Matthew Merrill Hayward, Jean-Baptiste Telliez, Rayomand Jal Unwalla, John I. Trujillo, Sidney Xi Liang
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The present invention provides pharmaceutically active pyrrolo[2,3-d]pyrimidinyl, pyrrolo[2,3-b]pyrazinyl, and pyrrolo[2,3-b]pyridinyl acrylamides, epoxides, and analogues thereof. Such compounds are useful for inhibiting Janus Kinase (JAK). This invention also is directed to compositions comprising methods for making such compounds, and methods for treating and preventing conditions mediated by JAK.
The compound 2-{[(2S)-1-acryloylpyrrolidin-2-yl]methoxy}-N-[(2S)-1-methoxypropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide;
The compound 2-[(1-acryloylpiperidin-4-yl)amino]-N-(3-fluorobenzyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide;
The compound 2-[(1-acryloylpiperidin-4-yl)amino]-N-(2-cyclopropylethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide;
The compound 2-[(1-acryloylpiperidin-4-yl)amino]-N-benzyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide;
The compound 2-[(1-acryloylpiperidin-4-yl)oxy]-N-[(2R)-1-methoxypropan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide;
Dependencies are inferred from the claim text.