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US 10,703,751 B2Granted
Amino-imidazopyridine derivatives as Janus kinase inhibitors and pharmaceutical use thereof
AssigneeLeo Pharma A/S
InventorsJens Larsen, Mogens Larsen, Lars Kyhn Rasmussen, Andreas Ritzen, Tine Marianne Duus
Life of this patent
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Abstract
The present invention relates to a compound according to formula (I) or pharmaceutically acceptable salts, hydrates, or solvates thereof; wherein R1 is C1-alkyl, R2 is C1-alkyl, R3 is C2-alkyl, R4 is hydrogen, R5 is hydrogen. The invention relates further to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to said compounds for use in the treatment autoimmune diseases and to intermediates for the preparation of said compounds.
Claims14
A compound according to general formula (I)
- wherein
- A represents C6-cycloalkyl, wherein said C6-cycloalkyl is optionally substituted with one or more deuterium;
- R1 represents C1-alkyl, wherein said C1-alkyl is optionally substituted with one or more deuterium;
- R2 represents C1-alkyl, wherein said C1-alkyl is substituted with a R6, and wherein said C1-alkyl is optionally substituted with one or more deuterium;
- R3 represents C2-alkyl, wherein said C2-alkyl is substituted with a R7, and wherein said C2-alkyl is optionally substituted with one or more deuterium;
- R4 represents hydrogen or deuterium;
- R5 represents hydrogen or deuterium;
- R6 represents cyano;
- and
- R7 represents hydroxyl;
- or a pharmaceutically acceptable salt, hydrate or solvate thereof.
8 more elements
The compound
- 2-[trans-4-[(5-Amino-2-chloropyridin-4-yl)amino]cyclohexyl]acetonitrile
- or a pharmaceutically acceptable salt hydrate, or solvate thereof.
A compound selected from
- (i) 2-[trans-4-[6-Chloro-2-(1-hydroxyethyl)-1H-imidazo[4,5-c]pyridin-1-yl]cyclo-hexyl]-acetonitrile,
- (ii) 2-[trans-4-[6-Chloro-2-[(1R)-1-hydroxyethyl]-1H-imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile, and
- (iii) trans-2-[4-[6-Chloro-2-(1,2,2,2-tetradeuterio-1-hydroxy-ethyl)imidazo[4,5-c]pyridin-1-yl]cyclohexyl]acetonitrile,
- or a pharmaceutically acceptable salt, hydrate, or solvate thereof.
1 more element
Dependencies are inferred from the claim text.