US 10,703,749 B2Granted

P2X7 modulators

AssigneeJanssen Pharmaceutica NV

InventorsManuel Jesus Alcazar Vaca, Jose Ignacio Andres Gil, Christa C. Chrovian, Heather R. Coate, Meri De angelis, Curt A. Dvorak, Christine F. Gelin, Michael A. Letavic, Brad M. Savall, Akinola Soyode-Johnson, Brice M. Stenne, Devin M. Swanson

Life of this patent

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Abstract

The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.

Claims6

Dependent claims

A compound, or pharmaceutically acceptable salt thereof, selected from the group consisting of:

Dependencies are inferred from the claim text.

Facts

Application: 16/196,140Filed 20 Nov 2018 · continuation
Priority: 14 Mar 2013
Published: US 2019/0092770 A128 Mar 2019
Granted: 7 Jul 2020
Term ends: Not estimatedThe source records don’t support an estimate.

Classification55 codes

C07D 471/04
In which the condensed system contains two hetero rings: ortho-condensed systems
A61K 31/497
Non-condensed pyrazines: containing further heterocyclic rings
A61P 1/00
Drugs for disorders of the alimentary tract or the digestive system
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…

Family

Application61/786,260Us provisional application · filed 14 Mar 2013
Application14/212,669Parent of this continuation · filed 14 Mar 2014
Application14/714,714Parent of this continuation · filed 18 May 2015
Application15/258,320Parent of this continuation · filed 7 Sep 2016
US 2019/0092770 A1Pre-grant publication · published 28 Mar 2019
US 10,150,765 B2Parent of this continuation
US 9,464,084 B2Parent of this continuation
US 9,066,946 B2Parent of this continuation
US 2014/0275015 A1Published application
US 2015/0322062 A1Published application
US 2016/0376271 A1Published application
US 10,703,749 B2This patent

From the US filing history. Foreign family members aren’t listed.

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