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US 10,703,744 B2Granted
Process for preparation of luliconazole
AssigneeGlenmark Life Sciences Limited
InventorsShekhar Bhaksar Bhirud, Kumar Hari Bhushan, Sunil Sudhakar Zhope, Shailesh Govind Ghadigaonkar, Pardeep Singh, Shekhar Ashok Deshmukh, Prem Chand
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Abstract
A process for the preparation of luliconazole and salts thereof is disclosed.
Claims9
A process for the purification of luliconazole, a compound of formula I, comprising the steps of
- (i) contacting a mixture comprising luliconazole and stereoisomers thereof in a solvent with an acid to provide a reaction mixture comprising an acid addition salt of luliconazole and an acid addition salt of stereoisomers of luliconazole, wherein the stereoisomers are the Z and SE isomers of luliconazole, the compound of formula VIII and IX respectively;
- (ii) separating the acid addition salt of luliconazole from the reaction mixture, and
- (iii) basifying the separated acid addition salt of luliconazole to form luliconazole, wherein
- (a) step (ii) comprises:
- (Gi) selectively separating the acid addition salt of luliconazole from the reaction mixture, where the reaction mixture comprises the acid addition salt of luliconazole and the acid addition salt of stereoisomer(s) of luliconazole, based on their differential solubility in solvents;
- and
- (Gii) isolating the acid addition salt of luliconazole, and
- (b) the acid addition salt of luliconazole is selectively separated by addition of an anti-solvent to the reaction mixture comprising the acid addition salt of luliconazole and the acid addition salt of stereoisomer(s) of luliconazole in a solvent.
5 more elements
A process for the purification of luliconazole, a compound of formula I, comprising the steps of
- (i) contacting a mixture comprising luliconazole and stereoisomers thereof in a solvent with an acid to provide a reaction mixture comprising an acid addition salt of luliconazole and an acid addition salt of stereoisomers of luliconazole, wherein the stereoisomers are the Z and SE isomers of luliconazole, the compound of formula VIII and IX respectively;
- (ii) separating the acid addition salt of luliconazole from the reaction mixture, and
- (iii) basifying the separated acid addition salt of luliconazole to form luliconazole, wherein
- (a) in step (i) the acid is hydrochloric acid;
- and
- (b) the acid addition salt of luliconazole obtained in step (ii) is crystalline luliconazole hydrochloride characterized by an X-ray diffraction (XRD) spectrum having peak reflections at about 4.0, 8.0, 11.9, 15.9 and 17.9±0.2 degrees 2 theta.
3 more elements
A process for the purification of luliconazole, a compound of formula I,
- the process comprising:
- (ii) contacting a mixture comprising luliconazole and stereoisomers thereof in a solvent with hydrochloric acid to provide a reaction mixture comprising luliconazole hydrochloride and any stereoisomers of luliconazole, wherein the stereoisomers are the Z and SE isomers of luliconazole, the compound of formula VIII and IX respectively
- (ii) separating the luliconazole hydrochloride from the reaction mixture of step (ii);
- and
- (iii) basifying the separated luliconazole hydrochloride to form luliconazole,
- wherein the luliconazole hydrochloride obtained in step (ii) is crystalline luliconazole hydrochloride characterized by an X-ray diffraction (XRD) spectrum having peak reflections at about 4.0, 8.0, 11.9, 15.9 and 17.9±0 0.2 degrees 2 theta.
3 more elements
Dependencies are inferred from the claim text.