Substituted benzimidazoles, their preparation and their use as pharmaceuticals

A compound of Formula III(a) or III(b):

• wherein,
• R1 is:
• a) an unsubstituted C1-C6alkyl;
• b) a C1-C6alkyl substituted with one or more group(s) selected from halogen, CN, NO2, C(O)NHR11, C(O)N(R11)2, CO2H, SO2R11, SO2NHR11, and SO2N(R11)2;
• c) a C2-C6alkyl group substituted with a group selected from OR11, halogenated OC1-C6alkyl, SH, SR11, NH2, NHR11, N(R11)2, NHC(O)R11, and N(R11)C(O)R11;
• or
• d) a group selected from C(O)R11, C(O)NHR11, C(O)N(R11)2, SO2NHR11, and SO2N(R11)2;
• R2 is tetrahydropyranyl;
• R7, R8, and R10 are each independently H, halogen, CN, or a substituted or unsubstituted C1-C6alkyl or C3-C6cycloalkyl group, OR11, SR11, NHR11) NHC(O)R11, and N(R11)C(O)R11, provided that at least one of R7, R8, and R10 is other than H;
• R9 is a substituted or unsubstituted C1-C3alkyl or C3-C5cycloalkyl group;
• R11 is, independently in each occurrence, a substituted or unsubstituted C1-C6alkyl group;
• wherein when any of the foregoing group contains an alkyl group, then said alkyl is a linear or branched acyclic alkyl group;
• and
• wherein when any of R7, R8, R9, R10, and R11 is substituted, it is substituted with one or more substituents selected from halogen, C1-C6alkyl optionally substituted with an oxo group, C1-C6alkoxy, and C1-C6aryl;
• or a pharmaceutically acceptable salt thereof.