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US 10,703,737 B2Granted
HDAC inhibitors and uses thereof
AssigneeMUSC Foundation for Research Development
InventorsDonald R. Menick, Chung-Jen James Chou, Daniel Herr, Xiaoyang Li
Life of this patent
Estimating the term…
Abstract
The present invention relates to histone deacetylase inhibitors, and to pharmaceutical compositions comprising the compounds, useful for the treatment of ischemia-reperfusion injury and for cardioprotection.
Claims4
A compound, or a pharmaceutically acceptable salt thereof, selected from the group consisting of:
- 2-(4-((2-(6-amino-3-iminio-3H-xanthen-9-yl)benzamido)methyl)benzamido) benzenaminium 2,2,2-trifluoroacetate (LL66);
- 2-(6-(2-(6-amino-3-iminio-3H-xanthen-9-yl)benzamido)hexanamido) benzenaminium 2,2,2-trifluoroacetate (LL38);
- 2-(7-(2-(6-amino-3-iminio-3H-xanthen-9-4)benzamido)heptanamido) benzenaminium 2,2,2-trifluoroacetate (LL45);
- 2-(8-(2-(6-amino-3-iminio-3H-xanthen-9-yl)benzamido)octanamido) benzenaminium 2,2,2-trifluoroacetate (LL130);
- 6-amino-9-(2-((4-(2-propylhydrazine-1-carbonyl)benzyl)carbamoyl)phenyl)-3H-xanthen-3-iminium 2,2,2-trifluoroacetate (LL65);
- 6-amino-9-(2-((7-oxo-7-(2-propylhydrazinyl)heptyl)carbamoyl)phenyl)-3H-xanthen-3-iminium 2,2,2-trifluoroacetate (LL142);
- 6-amino-9-(2-((2-oxo-2-((4-(2-propylhydrazine-1-carbonyl)benzyl)amino)ethyl) carbamoyl)phenyl)-3H-xanthen-3-iminium 2,2,2-trifluoroacetate (LL115);
- and
- 6-amino-9-(2-((2-oxo-2-((4-(2-propylhydrazine-1-carbonyl)phenypamino)ethyl) carbamoyl)phenyl)-3H-xanthen-3-iminium 2,2,2-trifluoroacetate (LL 162).
6 more elements
Dependencies are inferred from the claim text.