4-phenyl-coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer

A method of treating cancer by inhibiting POLRMT comprising administering a therapeutically effective amount of a compound of the general formula (I)

• wherein
• R is —H or —C1-C4-alkyl;
• R1 is —H or -methyl;
• R2 is —H;
• n=0, 1 or 2;
• X is -halogen, —C1-C4-alkyl, —OMe or —CN, with n=1 or 2;
• Y is —NR3R4 with
• R3 is —H, or —C1-C4-alkyl, and
• R4 is —H, —C1-C4-alkyl or —C3-C8-cycloalkyl;
• an unsubstituted or substituted pyridine residue;
• an unsubstituted or substituted pyridinylmethyl residue;
• an unsubstituted or substituted morpholinylethyl residue;
• an unsubstituted or substituted furanylmethyl residue;
• an unsubstituted or substituted phenyl residue;
• an unsubstituted or substituted benzyl residue;
• an unsubstituted or substituted phenethyl residue;
• the group
• or
• the group
• or
• Y is —NR3R4 with N, R3 and R4 forming an unsubstituted or substituted 5- or 6-membered saturated heterocycle,
• or
• Y is —OR1, with R11 is —H or —C1-C4-alkyl, phenyl, benzyl or 2-ethoxyethyl;
• and
• W1, W2, and W3 are identical or different, and are —H, -halogen, or —C1-C4-alkyl;
• or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof
• to a patient in need thereof.